R-universe - barryzee (barryzee)

randomGODB - Random GO Database

The Gene Ontology (GO) Consortium <https://geneontology.org/> organizes genes into hierarchical categories based on biological process (BP), molecular function (MF) and cellular component (CC, i.e., subcellular localization). Tools such as 'GoMiner' (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) can leverage GO to perform ontological analysis of microarray and proteomics studies, typically generating a list of significant functional categories. The significance is traditionally determined by randomizing the input gene list to computing the false discovery rate (FDR) of the enrichment p-value for each category. We explore here the novel alternative of randomizing the GO database rather than the gene list.

Last updated

3.48 score 5 dependents 197 downloads

GoMiner - Automate the Mapping Between a List of Genes and Gene Ontology Categories

In gene-expression microarray studies, for example, one generally obtains a list of dozens or hundreds of genes that differ in expression between samples and then asks 'What does all of this mean biologically?' Alternatively, gene lists can be derived conceptually in addition to experimentally. For instance, one might want to analyze a group of genes known as housekeeping genes. The work of the Gene Ontology (GO) Consortium <geneontology.org> provides a way to address that question. GO organizes genes into hierarchical categories based on biological process, molecular function and subcellular localization. The role of 'GoMiner' is to automate the mapping between a list of genes and GO, and to provide a statistical summary of the results as well as a visualization.

Last updated

3.38 score 4 dependents 582 downloads

minimalistGODB - Build a Minimalist Gene Ontology (GO) Database (GODB)

Normally building a GODB is fairly complicated, involving downloading multiple database files and using these to build e.g. a 'mySQL' database. Accessing this database is also complicated, involving an intimate knowledge of the database in order to construct reliable queries. Here we have a more modest goal, generating GOGOA3, which is a stripped down version of the GODB that was originally restricted to human genes as designated by the HUGO Gene Nomenclature Committee (HGNC) (see <https://geneontology.org/>). I have now added about two dozen additional species, namely all species represented on the Gene Ontology download page <https://current.geneontology.org/products/pages/downloads.html>. This covers most of the model organisms that are commonly used in bio-medical and basic research (assuming that anyone still has a grant to do such research). This can be built in a matter of seconds from 2 easily downloaded files (see <https://current.geneontology.org/products/pages/downloads.html> and <https://geneontology.org/docs/download-ontology/>), and it can be queried by e.g. w<-which(GOGOA3[,"HGNC"] %in% hgncList) where GOGOA3 is a matrix representing the minimalist GODB and hgncList is a list of gene identifiers. This database will be used in my upcoming package 'GoMiner' which is based on my previous publication (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003)<doi:10.1186/gb-2003-4-4-r28>). Relevant .RData files are available from GitHub (<https://github.com/barryzee/GO/tree/main/databases>).

Last updated

3.26 score 6 dependents 548 downloads

vprint - More Flexible Form of Boolean Verbose

R functions are not supposed to print text without giving the user the option to turn the printing off or on using a Boolean 'verbose' in a construct like 'if(verbose) print(...)'. But this black/white approach is rather rigid, and an approach with shades of gray might be more appropriate in many circumstances.

Last updated

3.18 score 5 dependents 146 downloads

HTGM - High Throughput 'GoMiner'

Two papers published in the early 2000's (Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) and (Zeeberg, B.R., Qin, H., Narashimhan, S., et al. (2005) <doi:10.1186/1471-2105-6-168>) implement 'GoMiner' and 'High Throughput GoMiner' ('HTGM') to map lists of genes to the Gene Ontology (GO) <https://geneontology.org>. Until recently, these were hosted on a server at The National Cancer Institute (NCI). In order to continue providing these services to the bio-medical community, I have developed stand-alone versions. The current package 'HTGM' builds upon my recent package 'GoMiner'. The output of 'GoMiner' is a heatmap showing the relationship of a single list of genes and the significant categories into which they map. 'High Throughput GoMiner' ('HTGM') integrates the results of the individual 'GoMiner' analyses. The output of 'HTGM' is a heatmap showing the relationship of the significant categories derived from each gene list. The heatmap has only 2 axes, so the identity of the genes are unfortunately "integrated out of the equation." Because the graphic for the heatmap is implemented in Scalable Vector Graphics (SVG) technology, it is relatively easy to hyperlink each picture element to the relevant list of genes. By clicking on the desired picture element, the user can recover the "lost" genes.

Last updated

2.95 score 3 dependents 607 downloads

HTGM2D - Two Dimensional High Throughput 'GoMiner'

The Gene Ontology (GO) Consortium <https://geneontology.org/> organizes genes into hierarchical categories based on biological process (BP), molecular function (MF) and cellular component (CC, i.e., subcellular localization). Tools such as 'GoMiner' (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) can leverage GO to perform ontological analysis of microarray and proteomics studies, typically generating a list of significant functional categories. Microarray studies are usually analyzed with BP, whereas proteomics researchers often prefer CC. To capture the benefit of both of those ontologies, I developed a two-dimensional version of 'High-Throughput GoMiner' ('HTGM2D'). I generate a 2D heat map whose axes are any two of BP, MF, or CC, and the value within a picture element of the heat map reflects the Jaccard metric p-value for the number of genes in common for the corresponding pair.

Last updated

2.78 score 2 dependents 254 downloads

HTGM3D - Three Dimensional High Throughput 'GoMiner'

Last updated

2.60 score 513 downloads

NoviceDeveloperResources - Resources to Assist Novice Developers

Assist novice developers when preparing a single package or a set of integrated packages to submit to CRAN. Automate the following individual or batch processing: check local source packages; build local .tar.gz source files; install packages from local .tar.gz files; detect conflicts between function names in the environment.

Last updated

2.48 score 1 dependents 587 downloads

textBoxPlacement - Compute a Non-Overlapping Layout of Text Boxes to Label Multiple Overlain Plots

Compute a non-overlapping layout of text boxes to label multiple overlain curves. For each curve, iteratively search for an adjacent x,y position for the text box that does not overlap with the other curves. If this process fails, then offsets are computed to add to the y values for each curve, that results in sufficient space to add all of the text labels.

Last updated

2.48 score 1 dependents 165 downloads

SherlockHolmes - Building a Concordance of Terms in a Series of Texts

Compute the frequency distribution of a search term in a series of texts. For example, Arthur Conan Doyle wrote a total of 60 Sherlock Holmes stories, comprised of 54 short stories and 4 longer novels. I wanted to test my own subjective impression that, in many of the stories, Sherlock Holmes' popularity was used as bait to induce the reader to read a story that is essentially not primarily a Sherlock Holmes story. I used the term "Holmes" as a search pattern, since Watson would frequently address him by name, or use his name to describe something that he was doing. My hypothesis is that the frequency distribution of the search pattern "Holmes" is a good proxy for the degree to which a story is or is not truly a Sherlock Holmes story. The results are presented in a manuscript that is available as a vignette and online at <https://barryzee.github.io/Concordance/index.html>.

Last updated

2.30 score 176 downloads

foodwebWrapper - Enhanced Wrapper to Show Which Functions Call What

Enhances the functionality of the mvbutils::foodweb() program. The matrix-format output of the original program contains identical row names and column names, each name representing a retrieved function. This format is enhanced by using the find_funs() program [see Sebastian (2017) <https://sebastiansauer.github.io/finds_funs/>] to concatenate the package name to the function name. Each package is assigned a unique color, that is used to color code the text naming the packages and the functions. This color coding is extended to the entries of value "1" within the matrix, indicating the pattern of ancestor and descendent functions.

Last updated

2.00 score 208 downloads

rankPlayedInference - Conditional Probability Distributions in Hearts Card Game

For a given suit, if you add up the number of cards that you hold, plus the number that has been played so far, you can easily determine the number that remains in the combined hands of your three opponents. You can also determine the ("special") card of highest rank of the remaining cards for that suit. At some point, you notice that a certain opponent discards that special card. What can you infer about his holding in that suit? A series of simulation studies are reported here that allows a quantitative inference based on the conditional probability, given that the opponent has the special card. The same procedure is also used for the conditional probability, given that the opponent does not have the special card.

Last updated

2.00 score

rankPlayedInference - Conditional Probability Distributions in Hearts Card Game

Last updated

2.00 score

HTGM4D - Four Dimensional High Throughput 'GoMiner'

The Gene Ontology (GO) Consortium <https://geneontology.org/> organizes genes into hierarchical categories based on biological process (BP), molecular function (MF) and cellular component (CC, i.e., subcellular localization). Tools such as 'GoMiner' (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003) <doi:10.1186/gb-2003-4-4-r28>) can leverage GO to perform ontological analysis of microarray and proteomics studies, typically generating a list of significant functional categories. Microarray studies are usually analyzed with BP, whereas proteomics researchers often prefer CC. To capture the benefit of both of those ontologies, I now present an enhancement of the existing two-dimensional version of 'High-Throughput GoMiner' ('HTGM2D'), which is called 'HTGM4D'. The original 'HTGM2D' is augmented by adding two instances of the original 'GoMiner' genes versus categories heatmaps, aligned with the categories axes of the 'HTGM2D' heatmap.

Last updated

2.00 score 478 downloads

runExamplesWrapper - Wrapper for 'run_examples()'

Captures errors encountered when running 'run_examples()', and processes and archives them. The function 'run_examples()' within the 'devtools' package allows batch execution of all of the examples within a given package. This is much more convenient than testing each example manually. However, a major inconvenience is that if an error is encountered, the program stops and does not complete testing the remaining examples. Also, there is not a systematic record of the results, namely which package functions had no examples, which had examples that failed, and which had examples that succeeded. The current package provides the missing functionality.

Last updated

2.00 score 475 downloads

myCRAN - Graph of Daily and Cumulative Downloads of your Packages

Plot the daily and cumulative number of downloads of your packages. It is designed to be slightly more convenient than the several similar programs. If you want to run this each morning, you do not need to keep typing in the names of your packages. Also, this combines the daily and cumulative counts in one run, you do not need to run separate programs to get both types of information.

Last updated

2.00 score 199 downloads

evenBreak - A Posteriori Probs of Suits Breaking Evenly Across Four Hands

We quantitatively evaluated the assertion that says if one suit is found to be evenly distributed among the 4 players, the rest of the suits are more likely to be evenly distributed. Our mathematical analyses show that, if one suit is found to be evenly distributed, then a second suit has a slightly elevated probability (ranging between 10% to 15%) of being evenly distributed. If two suits are found to be evenly distributed, then a third suit has a substantially elevated probability (ranging between 30% to 50%) of being evenly distributed.This package refers to methods and authentic data from Ely Culbertson <https://www.bridgebum.com/law_of_symmetry.php>, Gregory Stoll <https://gregstoll.com/~gregstoll/bridge/math.html>, and details of performing the probability calculations from Jeremy L. Martin <https://jlmartin.ku.edu/~jlmartin/bridge/basics.pdf>, Emile Borel and Andre Cheron (1954) "The Mathematical Theory of Bridge",Antonio Vivaldi and Gianni Barracho (2001, ISBN:0 7134 8663 5) "Probabilities and Alternatives in Bridge", Ken Monzingo (2005) "Hand and Suit Patterns" <http://web2.acbl.org/documentlibrary/teachers/celebritylessons/handpatternsrevised.pdf>Ken Monzingo (2005) "Hand and Suit Patterns" <http://web2.acbl.org/documentlibrary/teachers/celebritylessons/handpatternsrevised.pdf>.

Last updated

2.00 score 156 downloads

conditionalProbNspades - Conditional Probabilities of Distributions Across Hearts Hands

Provides some tabulated data to be be referred to in a discussion in a vignette accompanying my upcoming R package 'playWholeHandDriverPassParams'. In addition to that specific purpose, these may also provide data and illustrate some computational approaches that are relevant to card games like hearts or bridge.This package refers to authentic data from Gregory Stoll <https://gregstoll.com/~gregstoll/bridge/math.html>, and details of performing the probability calculations from Jeremy L. Martin <https://jlmartin.ku.edu/~jlmartin/bridge/basics.pdf>.

Last updated

2.00 score 150 downloads

clickableImageMap - Implement 'tableGrob' Object as a Clickable Image Map

Implement 'tableGrob' object as a clickable image map. The 'clickableImageMap' package is designed to be more convenient and more configurable than the edit() function. Limitations that I have encountered with edit() are cannot control (1) positioning (2) size (3) appearance and formatting of fonts In contrast, when the table is implemented as a 'tableGrob', all of these features are controllable. In particular, the 'ggplot2' grid system allows exact positioning of the table relative to other graphics etc.

Last updated

2.00 score 189 downloads

NoviceDeveloperResources2 - Further Resources to Assist Novice Developers

Assist novice developers when preparing a single package or a set of integrated packages to submit to CRAN. Provide additional resources to facilitate the automation of the following individual or batch processing: check local source packages; build local .tar.gz source files; install packages from local .tar.gz files; detect conflicts between function names in the environment. The additional resources include determining the identity and ordering of the packages to process when updating an imported package.

Last updated

2.00 score 122 downloads

timeLineGraphics - HTML with Horizontal Strips Symbolizing Events in a Person's Life

Produce an HTML page containing horizontal strips that symbolize events in a person's lsife. Since this is entirely a visualization, the image <https://barryzee.github.io/henry-timeline/henry.html> will show the basic use to show a timeline of events. The image <https://barryzee.github.io/vermeer/cssOverlay.html> shows how to correlate two timelines of events. A brief description is available at <https://barryzee.github.io/timeLineGraphics_manuscript/golden_age.html>.

Last updated

2.00 score 178 downloads